- 姓名: 馬慧敏
- 性別: 女
- 職務:
- 職稱: 特任研究員
- 學歷: 博士研究生
- 電子郵件: mahuimin@gig.ac.cn
馬慧敏,特任研究員,碩士生導師。2009年畢業(yè)于中國科學院廣州地球化學研究所環(huán)境科學專業(yè),獲博士學位。主要從事環(huán)境健康方向研究。截至2026年1月,已發(fā)表/被接收學術論文54篇(第一作者或通訊作者22篇),申請專利2項?,F(xiàn)任[International Journal of Environmental Epidemiology]等雜志的編委、[廣東省環(huán)境誘變劑學會]副監(jiān)事長等。
簡 歷:
社會任職:
從事環(huán)境污染物的早期健康效應研究,研究環(huán)境中的重金屬、大氣細顆粒物(包括PM2.5和PM0.1)等對人體健康的影響,構建新一代健康風險評估模型。利用環(huán)境有機地球化學、流行病學、和毒理學等方法,篩選重金屬暴露對兒童智力發(fā)育的影響及其特異性定量生物標志物,構建精準風險評估模型;篩選和鑒定大氣顆粒物中的有效毒性種類,鑒定特異性生物標志物,并結合同位素技術進行源解析,構建“毒物篩查-毒物機制-風險評估”鏈條。
研究方向:
?
獲獎及榮譽:
[1]. Cong Wan, Huimin Ma*, Xiaowen Zeng*, Guanghui Dong, Jian Chen, Jing You, Fei Cheng, Yuan Luo, Kevin Jones, Gan Zhang, Zhiqiang Yu*, Pingan Peng, DNA methylation of FAM50B/PTCHD3 mediates the relationships between low blood lead exposure and neurobehavioral development of 0-3 aged infants: a prospective birth cohort study in southern China, Environment Health, 2025, https://doi.org/10.1021/envhealth.5c00459 . (IP=6.3)
[2].Huimin Ma,* Haonan Jie, Qianyu Zhang, Cong Wan, Jing You, Guanghui Dong, Xinyu Liu, ZhiqiangYu, Jun Li, and Gan Zhang. Polycyclic nitroaromatic compounds in HULIS as dominant pro-apoptotic agents in PM2.5: Biomass/coal combustion sources, structural insights, and biomarker discovery. Ecotoxicology and Environmental Safety, 2025, 307(15). https://doi.org/10.1016/j.ecoenv.2025.119399 (IP=6.4)
[3].Qianyu Zhang, Huimin Ma,* Jun Li,* Fei liu, Hongxing Jiang, Jinbo Huang,Bin Jiang, Jing You, Guanghui Dong,Qilu Li,Wanli Ma,ZhiqiangYu, and Gan Zhang. Unveiling Condensed Aromatic Amines as Noteworthy Genotoxic Components in PM2.5 Dissolved Organic Matter. Environmental Science & Technology 2025; DOI: 10.1021/acs.est.5c07412 . (IP=11.4,NI指數(shù)期刊)(內封面文章)
[4].Qianyu Zhang, Huimin Ma*, Jun Li*, Hongxing Jiang, Wenjing Chena, Cong Wan, Bin Jiang, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Shaoyou Lu, Jing You, Zhiqiang Yu, Xinming Wang, Gan Zhang, Nitroaromatic compounds from secondary nitrate formation and biomass burning are major pro-inflammatory components in organic aerosols in Guangzhou: a bioassay combining high-resolution mass spectrometry analysis, Environmental Science& Technology, 2023, 57(51):21570-21580, https://doi.org/10.1021/acs.est.3c04983 . (IP=11.4,NI指數(shù)期刊)(內封面文章)
[5].Cong Wan , Huimin Ma*, Jiahong Liu , Fei Liu, Jing Liu, Guanghui Dong, Xiaowen Zeng, Daochuan Li, Zhiqiang Yu , Xinming Wang, Jun Li, Gan Zhang, Environ. Quantitative relationships of FAM50B and PTCHD3 methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and in vitro studies. Science Of The Total Environment, 2023.167976, https://doi.org/10.1016/j.scitotenv.2023.
167976.? (IP=10.75)
[6].Huimin Ma*, Wenjing Chen, Qianyu Zhang, Cong Wan, Yangzhi Mo, Fei Liu, Guanghui Dong, Xiaowen Zeng, Duohong Chen, Zhiqiang Yu, Jun Li, Gan Zhang. Pollution source and chemicals structure of the water-soluble fractions in PM2.5 that induce apoptosis in China, Environment International, 173:107820, https://doi.org/10.1016/j.envint.2023.107820 (IP=11.8)
[7].Cong Wan, Shangxia Pan, Lifeng Lin, Jun Li, Guanghui Dong, Kevin C. Jones, Fei Liu, Daochuan Li, Jing Liu, Zhiqiang Yu, Gan Zhang, and Huimin Ma*, DNA Methylation Biomarkers of IQ Reduction are Associated with Long Term Lead Exposure in School Aged Children in Southern China . Environmental Science& Technology, 2021, 55(1): 412–422, http://dx.doi.org/10.1021/acs.est. 0c01696;? (IP=11.4,NI指數(shù)期刊)
[8].Yaohui Liang, Liwen Hu, Jun Li, Fei Liu, Kevin C. Jones, Daochuan Li, Jing Liu, Duohong Chen, Jing You, Zhiqiang Yu, Gan Zhang, Guanghui Dong, Huimin Ma*, Short-term personal PM2.5 exposure and change in DNA methylation of imprinted genes: Panel study of healthy young adults in Guangzhou city, China, Environmental Pollution, 2021,15(275):116601, doi: 10.1016/j.envpol.2021. 116601.(IP=8.9)
[9].Huimin Ma, Jun Li, Cong Wan, Yaohui Liang, Xiangyun Zhang, Guanghui Dong, Liwen Hu, Boyi Yang, Xiaowen Zeng, Tao Su, Shaoyou Lu, Shejun Chen, Mahdi Safaei Khorram, Guoying Sheng, Xinming Wang, Bixian Mai, Zhiqiang Yu*, Gan Zhang*, Inflammation response of water-soluble fractions in atmospheric fine particulates: a seasonal observation in 10 large Chinese cities, Environmental Science& Technology. 2019, 53(7):3782-3790. (IP=11.4,NI指數(shù)期刊) (內封面文章)
[10].Shangxia Pan, Lifeng Lin, Fan Zeng, Jianpeng Zhang, Guanghui Dong, Boyi Yang, You Jing, Shejun Chen, Gan Zhang, Zhiqiang Yu, Guoying Sheng, Huimin Ma*, Effects of lead, cadmium, arsenic, and mercury co-exposure on children's intelligence quotient in an industrialized area of southern China, Environmental Pollution, 2018, 20(235):47-54. (IP=8.9)
[11].Liudan Zeng, Huimin Ma*, Shangxia Pan, Jing You, Gan Zhang, Zhiqing Yu,? Guoying Sheng, Jiamo Fu,LINE-1 gene hypomethylation and p16 gene hypermethylation in HepG2 cells induced by low-dose and long-term Triclosan exposure: The role of hydroxyl group, Toxicology in vitro, 2016,34:35-44. (IP=3.2)
[12].Junjie Hu, Huimin Ma*, Wenbing Zhang*, Zhiqing Yu, Guoying Sheng, Jiamo Fu,Effects of benzene and its metabolites on global DNA methylation in human normal hepatic L02 cells, Environmental Toxicology. 2014, 29:108-116. (IP=4.35)
[13].Huimin Ma*, Liujin Zheng, Yuhua Li, Shaxia Pan, Zhiqiang Yu, Gan Zhang, Guoying Sheng, Jiamo Fu,Triclosan Reduces the Levels of Global DNA Methylation in HepG2 Cells,Chemosphere, 2013,90:1023-1029. (IP=7.09)
[14].Junjie Hu, Wenbing Zhang*, Huimin Ma*, Yunmei Cai, Guoying Sheng, Jiamo Fu.Simultaneous determination of 8-hydroxy-2 '-deoxyguanosine and 5-methyl-2 '-deoxycytidine in DNA sample by highperformance liquid chromatography/positive electrospray ionization tandem mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2010, 878:2765-2769.? (IP=3.21)
[15].Huimin Ma, Wenbing Zhang*, Junjie Hu, Zhiqiang Yu, Yong Chen, Qiong luo, Xiaoliu Shi, Yingying Zhang, Renfang Song, Zhen Zhou, Guoying Sheng and Jiamo Fu, “Analysis of global DNA methylation level in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry (HPLC-ESI-MS/MS)”, European Journal of Mass Spectrometry, 2009,15: 555-561.? (IP=1.3)
[16].Huimin Ma, Wenbing Zhang*, Renfang Song, Huayong Chen, Guoying Sheng, Zhen Zhou and Jiamo Fu, “Characterization of methylated and unmethlyated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry”, European Journal of Mass Spectrometry, 2005,11:581-589;(IP=1.3)
[17].劉家宏,萬 聰,潘尚霞 , 馬慧敏*,某工業(yè)區(qū)誘導兒童神經(jīng)損傷的關鍵重金屬及暴露途徑,地球化學,2024,已接收
[18].潘尚霞,馬慧敏*,林立豐,張建鵬,萬聰,環(huán)境鉛暴露對兒童智力和精神運動功能影響研究,華南預防醫(yī)學,2017,5:412-417。
[19].曾柳丹,馬慧敏,*, 張干, 于志強, 盛國英,傅家謨, BDE-208和BDE-209誘導了LINE-1基因低甲基化和ESR1基因高甲基化,生態(tài)毒理學報,2016,2:163-169。
[20].王晶晶、馬慧敏*、李寶才*、鄭劉進、潘尚霞、黎玉華、盛國英、傅家謨,苯代謝物氫醌對人體肝細胞內DNA甲基轉移酶基因和蛋白表達的影響 ,昆明理工大學學報(自然科學版), 2013,38:90-95.
[21].胡俊杰、馬慧敏*、張文兵、李林朋、于志強、盛國英、傅家謨,苯急性暴露對Sprague-Dawley大鼠全基因組DNA 甲基化的影響,生態(tài)環(huán)境學報,2010, 19(12):2902-2905.
[22].馬慧敏,張文兵*,施小六,于志強,胡俊杰,宋任芳,盛國英,傅家謨, “人體結腸癌組織樣品中基因組DNA甲基化水平的HPLC-ESI-MS/MS檢測”,分析測試學報, 2009, 5:292-296.
代表論著:
[1].國家自然科學面上項目,項目名稱:“基于定組人群實驗的空氣顆粒物有毒污染物篩查及其主要污染源研究”,2025年1月到2028年12月,經(jīng)費47萬,項目號:42477257,課題負責人;
[2].國家自然科學面上項目,項目名稱:“大氣細顆粒物中類腐殖酸類化合物的有效毒性組分的篩選和鑒定”,2021年1月到2024年12月,經(jīng)費57萬,項目號:42077197,課題負責人;
[3].廣州市科技菁英“領航”計劃,項目名稱“廣州市PM2.5中類腐殖酸類化合物(HULIS)誘發(fā)炎癥與氧化應激的關鍵化合物篩選”,2025年1月到2027年12月,經(jīng)費:30萬, 課題負責人;
[4]廣東省自然科學基金,面上項目, 低濃度血鉛暴露對兒童神經(jīng)發(fā)育和智力影響的定量DNA甲基化生物標志物研究,項目號:2025A1515012195, 2025.01-2027.12, 10萬,課題負責人;
[5].廣東省基礎與應用基礎研究重大項目,項目名稱“大灣區(qū)毒害污染物多介質過程與風險管控”,2023年9約- 2028年9月,項目經(jīng)費:2000萬,項目號:2023B0303000007,技術骨干;
[6].國家重點研發(fā)計劃國合專項,2018YFE0106900,交通源超細顆粒物暴露與神經(jīng)退行性疾病風險評估的關鍵技術及應用,2018YFE0106900, 2019年7月至2022年6月,570萬,第三課題負責人;
[7].廣東省自然科學基金,面上項目,2019A1515011859, 血鉛誘導兒童智力降低的DNA甲基化生物標志物的初步鑒定,2019-10至2022-9, 10萬,主持人;
[8]. 廣州市科技計劃項目,項目名稱:“廣州市PM2.5中不同來源的類腐殖酸類化合物對人體肺細胞的毒性貢獻”,2021年3月-2023年3月,經(jīng)費:5萬,主持人。
[9].國家基金重點項目,項目名稱 “大氣顆粒物中多環(huán)芳香有機質(POM)化學組成與毒性的分布和演化”, 2021年1月到2025年12月, 經(jīng)費:304萬,項目號:42030715,技術骨干;
[10].廣州市科技計劃科學研究專項重點項目,201707020033,廣州不同典型區(qū)域大氣顆粒物中的毒害有機物及毒性效應,2017-5至2020-12, 200萬元,技術骨干;
[11].國家自然科學青年基金,21007072, HPLC-MS/MS內標法研究典型污染物對人體DNA甲基化的影響,2011-1至2013-12,19 萬元,主持;
[12].中國科學院知識創(chuàng)新工程重要方向項目, KZCX2-YW-GJ02, 南亞POPs污染及其跨境遷移趨向, 2010-1至2012-1, 190萬元,第二課題主持人;
[13].中國科學院廣州地球化學研究所知識創(chuàng)新領域前沿項目,GIGCX-09-01,苯及其代謝物對人體肝臟和骨髓細胞基因的甲基化影響, 2009-11至2011-11, 20萬元,主持人。

研究隊伍